Dissociation equilibrium constant of beta nerve growth factor
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چکیده
منابع مشابه
Dissociation Equilibrium Constant of /I Nerve Growth Factor*
The j3 nerve growth factor (NGF) isolated from the high molecular weight 7 S NGF complex from mouse submaxillary gland is a protein of molecular weight 26,500 which contains two noncovalently associated peptide chains. A variety of techniques were employed to determine whether the NGF dimer dissociates at the low concentrations at which it is biologically active. No dissociation was detected in...
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The cell surface receptor for beta-nerve growth factor was used as a probe to study the development of embryonic chick sensory ganglia. The ganglia were shown to lose their responsiveness to nerve growth factor in vitro between 14 and 16 days of embryonic age. This loss occurred by a decrease in the magnitude of the maximum biological response, not by a shifting of the response to higher concen...
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Nerve growth factor (NGF) is partially modified at its NH2 terminus during purification from mouse submaxillary gland. The significance of the cleavage of a histidine/methionine bond to produce an octapeptide from the NH2 terminus of PNGF is not yet understood. This study is concerned with the purification and characterization of the endopeptidase responsible for the cleavage and with its physi...
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We previously reported that the precursor form of nerve growth factor (pro-NGF) and not mature NGF is liberated in the CNS in an activity-dependent manner, and that its maturation and degradation occur in the extracellular space by the coordinated action of proteases.Here, we present evidence of diminished conversion of pro-NGF to its mature form and of greater NGF degradation in Alzheimer dise...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1977
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(19)75252-1